* In 1968, when Grammer was thirteen, his father was murdered on the front lawn of his home in the U.S. Virgin Islands
* In 1975, his sister was raped and murdered after being abducted outside a Red Lobster restaurant in Colorado Springs, Colorado where her boyfriend worked. Grammer has sworn to prevent the murderer from being paroled.
* In 1980, his twin half-brothers were killed in a SCUBA diving accident.
* His second marriage, to stripper Leigh-Anne Csuhany in 1992, lasted one year. Grammer claims she was abusive and that, after talk of divorce, she attempted suicide, which resulted in the miscarriage of their child.
* His engagement to Tammi Alexander broke up due to rape allegations and her leaks to the tabloid press.
* Since August 1997 Grammer has been married to Camille Donatacci, a former Playboy model.
* In 1988, he was sentenced to 30 days in jail for drunk driving and cocaine possession.
* He was again arrested for cocaine possession in August 1990 and sentenced to three years' probation
* In January 1991 he was given an additional two years' probation for violating his original probation through additional cocaine use.
* In September 1996, he overturned his Dodge Viper while under the influence of drugs or alcohol and subsequently checked in to the Betty Ford Clinic for 30 days.
* During an appearance on Hannity & Colmes on Fox News, Grammer expressed an interest in running for United States Congress as a Republican.
* He was a celebrity guest at President George W. Bush's first inauguration.